Nature Biotechnology, Published online: 23 October 2023; doi:10.1038/s41587-023-02003-3Using an experimental and computational framework inspired by compressed sensing, we greatly reduced the number of measurements needed to run Perturb-seq. Our compressed Perturb-seq strategy relies on collecting measurements comprising random linear combinations of genetic perturbations, followed by deconvolving the perturbation effects on the transcriptome using sparsity-exploiting algorithms…
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Compressed Perturb-seq enables highly efficient genetic screens
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